The present study will characterize the functional role of Dcn in the retina and test the potential of AAV5- Dcn gene therapy for the treatment of retinopathy of prematurity using an established oxygen-induced retinopathy rat model.
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This is the first study to describe the ultrastructural neuronal and vascular changes in the retina of young Ossabaw pigs fed a Western diet, simulating early signs of diabetic retinopathy pathogenesis. Research Statement. Role of S proteins in Diabetic Retinopathy. Results: Normal trabecular tissue showed well-defined, thin, cylindrical uveal trabecular beams with many large spaces, overlying flatter corneoscleral beams and numerous smaller spaces.
In acute PACG eyes, the trabecular meshwork showed grossly swollen, irregular trabecular endothelial cells with intercellular and occasional basal separation with few spaces.
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Numerous activated macrophages, leucocytes and amorphous debris were present. Chronic PACG eyes had a few, thickened posterior uveal trabecular beams visible. A homogenous deposit covered the anterior uveal trabeculae and spaces. Converging, fan-shaped trabecular beam configuration corresponded to gonioscopic areas of peripheral anterior synechiae.
In POAG eyes, anterior uveal trabecular beams were thin and strap-like, while those posteriorly were wide, with a homogenous deposit covering and bridging intertrabecular spaces, especially posteriorly. Underlying corneoscleral trabecular layers and spaces were visualized in some areas. Chronically raised IOP in chronic PACG and POAG probably results, at least in part, from decreased aqueous outflow secondary to widening and fusion of adjacent trabecular beams, together with the homogenous deposit enmeshing trabecular beams and spaces.
- Current Research in Ophthalmic Electron Microscopy door M. Spitznas (Boek) - tuhupersgentcomp.cf;
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Advanced Search. The number of people with glaucoma worldwide in and Br J Ophthalmol ; Lee WR. The pathology of the outflow system in primary and secondary glaucoma. Eye ; Tripathi RC.
Aqueous outflow pathway in normal and glaucomatous eyes. The trabecular meshwork in acute and chronic angle closure glaucoma. Indian J Ophthalmol ; Trabecular meshwork cellularity in primary open angle glaucoma and nonglaucomatousnormals. Ophthalmology ; Obstruction of trabecular orifices in primary open angle glaucoma. Eur J Anat ; Sampaolesi R, Argento C. Scanning electron microscopy of the trabecular meshwork in normal and glaucomatous eyes.
Invest Ophthalmol Vis Sci ; Scanning electron microscopy of human ocular tissues: Trabecular meshwork. Scanning electron microscopy of trabeculectomy specimens in open angle glaucoma. Am J Ophthalmol ; Grierson I, Lee WR.
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